Este fin de semana disfrute de su vino preferido sabiendo que le ayuda a proteger su salud. Lea estas evidencias científicas recientes
This weekend enjoy your favorite wine knowing that it helps to protect your health. Read these recent scientific evidence
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| Vino rojo, vino blanco, vino rosado y jugo de uva inhiben la enzima convertidora de angiotensina en las células humanas endoteliales |
Red wine, white wine, rosé wine, and grape juice inhibit angiotensin-converting enzyme in human endothelial cells.
Persson I.
Int J Nutr Pharmacol Neurol Dis [serial online] 2013 [cited 2013 Feb 22];3:17-23
Background: Beneficial effects of wine on cardiovascular disease have been shown previously, but the mechanism is still unknown. The renin-angiotensin system is an important mechanism in the body concerning regulation of blood pressure, fluid, and electrolyte balance, and the angiotensin-converting enzyme (ACE) is a key enzyme in this system. Aims: The aim of this study was to investigate the effect of red wine, white wine, rosι wine, and alcohol-free grape juice on somatic ACE-1 activity. The effects of the stilbene resveratrol and its glycoside, resveratrol-3-glycoside were also tested on ACE activity and concentration of nitric oxide (NO). Materials and Methods: Cultured endothelial cells from human umbilical veins (HUVEC) were incubated with wine, grape juice, resveratrol, or resveratrol-3-glycoside. Ethanol was used as control in the corresponding concentration (13%). Results: After incubation, a significant inhibition of ACE activity was seen with all the wines tested and the red grape juice. This inhibition was of a similar magnitude except for a lesser inhibition with the rosι wine. No significant inhibition was seen with the white grape juice, resveratrol, resveratrol-3-glycoside, or ethanol alone, and neither did resveratrol nor resveratrol-3-glycoside affect the concentration of NO. Conclusions: The effect of wine and grape juice on ACE activity in HUVEC is dependent on the amount of flavonoids and not on the content of alcohol or resveratrol.
Keywords: ACE, cardiovascular disease, ethanol, grape juice, resveratrol, wine
http://www.ijnpnd.com/text.asp?2013/3/1/17/106975
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| Potenciales propiedades anticancerosas de los antioxidantes de la uva |
Potential anticancer properties of grape antioxidants.
Zhou K, Raffoul JJ.
Department of Nutrition and Food Science, Wayne State University, Detroit, MI 48202, USA.
J Oncol. 2012;2012:803294. doi: 10.1155/2012/803294. Epub 2012 Aug 7.
Abstract
Dietary intake of foods rich in antioxidant properties is suggested to be cancer protective. Foods rich in antioxidant properties include grape (Vitis vinifera), one of the world's largest fruit crops and most commonly consumed fruits in the world. The composition and cancer-protective effects of major phenolic antioxidants in grape skin and seed extracts are discussed in this review. Grape skin and seed extracts exert strong free radical scavenging and chelating activities and inhibit lipid oxidation in various food and cell models in vitro. The use of grape antioxidants are promising against a broad range of cancer cells by targeting epidermal growth factor receptor (EGFR) and its downstream pathways, inhibiting over-expression of COX-2 and prostaglandin E2 receptors, or modifying estrogen receptor pathways, resulting in cell cycle arrest and apoptosis. Interestingly, some of these activities were also demonstrated in animal models. However, in vivo studies have demonstrated inconsistent antioxidant efficacy. Nonetheless, a growing body of evidence from human clinical trials has demonstrated that consumption of grape, wine and grape juice exerts many health-promoting and possible anti-cancer effects. Thus, grape skin and seed extracts have great potential in cancer prevention and further investigation into this exciting field is warranted.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420094/pdf/JO2012-803294.pdf
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| Polifenoles del vino: agentes potenciales en la neuroprotección |
Wine polyphenols: potential agents in neuroprotection.
Basli A, Soulet S, Chaher N, Mérillon JM, Chibane M, Monti JP, Richard T.
GESVAB, ISVV, Université de Bordeaux, France.
Oxid Med Cell Longev. 2012;2012:805762. doi: 10.1155/2012/805762. Epub 2012 Jul 5.
Abstract
There are numerous studies indicating that a moderate consumption of red wine provides certain health benefits, such as the protection against neurodegenerative diseases. This protective effect is most likely due to the presence of phenolic compounds in wine. Wine polyphenolic compounds are well known for the antioxidant properties. Oxidative stress is involved in many forms of cellular and molecular deterioration. This damage can lead to cell death and various neurodegenerative disorders, such as Parkinson's or Alzheimer's diseases. Extensive investigations have been undertaken to determine the neuroprotective effects of wine-related polyphenols. In this review we present the neuroprotective abilities of the major classes of wine-related polyphenols.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399511/pdf/OXIMED2012-805762.pdf
Atentamente
Anestesiología y Medicina del Dolor
www.anestesia-dolor.org
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