Emerging evidence suggests that osteoarthritis (OA) has a neuropathic component; however, the identity of the molecules responsible for this peripheral neuropathy is unknown. The aim of this study was to determine the contribution of the bioactive lipid lysophosphatidic acid (LPA) to joint neuropathy and pain.
Intra-articular injection of LPA caused knee joint neuropathy, joint damage and pain. Pharmacological blockade of LPA receptors inhibited joint nerve damage and hindlimb incapacitance. Thus, LPA is a candidate molecule for the development of OA nerve damage and the origin of joint neuropathic pain.
Evidencia emergente sugiere que la osteoartritis (OA) tiene un componente neuropático; Sin embargo, la identidad de las moléculas responsables de esta neuropatía periférica es desconocida. El objetivo de este estudio fue determinar la contribución del ácido lisofosfatídico lipídico bioactivo (LPA) a la neuropatía y dolor articular.CONCLUSIÓN:
La inyección intraarticular de LPA causó neuropatía en la articulación de la rodilla, daño en las articulaciones y dolor. El bloqueo farmacológico de los receptores de LPA inhibió el daño nervioso de las articulaciones y la incapacidad de los miembros posteriores. Por lo tanto, el LPA es una molécula candidata para el desarrollo del daño del nervio OA y el origen del dolor neuropático articular.PALABRAS CLAVE:
Edited by Arshad M. Malik, ISBN 978-953-51-2964-6, Print ISBN 978-953-51-2963-9, 142 pages, Publisher: InTech, Chapters published February 22, 2017 under CC BY 3.0 license
Laparoscopic surgery developed as the most element change ever in the history of surgery. The approach of this method is no more a late headway. The history goes back three decades now when appendectomy was initially performed laparoscopically in 1983. It was then polished by not very many specialists, and there was a moderate move of the method from traditional open surgery to laparoscopic surgery. Hesitance to take in an absolutely new method, absence of facilities, and appropriate training were main considerations ruining its direction. After an underlying hindered period came a sudden ascent in the worldwide preoccupation of the consideration toward this novel strategy. There was an aggregate move from open to laparoscopic surgery in a large portion of the focuses with an expanding rundown of operations being performed laparoscopically. This book is intended to bring forward the very many advancements in the field of laparoscopic surgery. There are many valuable contributions from eminent laparoscopic surgeons ranging from diagnostic to therapeutic procedures performed by this technique. I hope it will benefit the trainee surgeons as well as the experienced alike. Suggestions and positive criticism are more than welcome.
Edited by Nancy Dumais, ISBN 978-953-51-2962-2, Print ISBN 978-953-51-2961-5, 172 pages, Publisher: InTech, Chapters published February 22, 2017 under CC BY 3.0 license
With increasing efficacy of antiretroviral therapy, HIV/AIDS has shifted from a disease with high mortality to a chronic illness with substantial longevity. However, researchers, physicians and social workers still face many challenges, and it is important to raise awareness on several aspects that people living with HIV/AIDS have to deal in their daily lives. This book has assembled an array of chapters on the medical, social and economic aspects of HIV/AIDS. The chapters were written by experts from around the globe reflecting the importance of the topic. This book will be of great interest not only to graduate students but also to active academics and practitioners.
Edited by Kaan Kirali, ISBN 978-953-51-2934-9, Print ISBN 978-953-51-2933-2, 202 pages, Publisher: InTech, Chapters published February 22, 2017 under CC BY 3.0 license
Aortic aneurysms are very silent, insidious, and sudden complicated pathologies with high incidence of sudden death. The aorta has several different parts, which are affected by aneurysmal pathology independently and separately or conjointly. Preventive medicine and determinative genetic heritage are the first steps during diagnosis and precaution. Preventive screening of the general population seems the best way for diagnosing early asymptomatic aneurysms with increased health cost. Because sudden death is the first symptom of aortic aneurysms, early interventional treatment is essential to protect fatal complications. In spite of open surgical repair which is the standard procedure, isolated or hybrid endovascular approaches are used widespread in the last decade due to reduction of procedural complications. This book is composed of the main topics on aortic aneurysms and surgical treatments to extend scientific and therapeutic perspective and vision of cardiac teams.
Courtesy: Prof Nabil Ebraheim, University of Toledo, Ohio, USA
Dr. Ebraheim’s educational animated video describes the fracture complications in children, how to prevent it, diagnose it, and treat it.
Become a friend on facebook: http://www.facebook.com/drebraheim